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I had my last Depo injection on the 20th of March, and I let my now husband give me the shot, however I don't think it took. The injection site on my arm was a huge bump, and it was red and warm....anyways, I just recently got married on May 1st, and as you can imagine, we were very active for about a week. My sister swears that I have had a "glow" for about 3 weeks now. I have been taking tests like they're going out of style, and they're all negative. I do however have the night-time sickness, headaches (severe at times), slept for almost 3 days straight, and heartburn like crazy. I have had more than a few people tell me that they think I am pregnant, but I'm not sure with all the negative tests, and just getting off the depo recently. Could it really be???